HRT Preparations (USA)
American information
Brand |
Active
Ingredients |
Description |
Strengths |
Frequency of
Dosing |
ESTROGEN (ORAL) | ||||
CENESTIN | Synthetic conj. estrogens, A | Tablets | 0.3mg, 0.45mg, 0.625mg, 0.9mg, 1.25mg | Once daily |
ENJUVIA | Synthetic conj. estrogens, B | Tablets | 0.3mg, 0.45mg, 0.625mg, 0.9mg, 1.25mg | Once daily |
ESTRACE | Estradiol (micronized) | Tablets | 0.5mg, 1mg, 2mg | Once daily |
FEMTRACE | Estradiol | Tablets | 0.9mg, 1.8mg | Once daily |
MENEST | Esterified estrogens | Tablets | 0.3mg, 0.625mg, 1.25mg, 2.5mg | Once daily |
OGEN | Estropipate1 | Tablets | 0.625mg, 1.25mg, 2.5mg | Once daily |
ORTHO-EST | Estropipate1 | Tablets | 0.625mg, 1.25mg | Once daily |
PREMARIN | Conj. estrogens | Tablets | 0.3mg, 0.45mg, 0.625mg, 0.9mg, 1.25mg, 2.5mg | Once daily |
ESTROGEN (TRANSDERMAL) | ||||
ALORA | Estradiol | Patch (matrix) | 0.025, 0.05, 0.075, 0.1mg/day | Twice weekly |
CLIMARA | Estradiol | Patch (matrix) | 0.025, 0.0375, 0.05, 0.06, 0.075, 0.1mg/day | Once weekly |
DIVIGEL | Estradiol | Gel (topical) | 0.25, 0.5, 1mg/packet | Once daily |
ELESTRIN | Estradiol | Gel (topical) | 0.87g/pump | Once daily |
ESTRADERM | Estradiol | Patch (reservoir) | 0.05, 0.1mg/day | Twice weekly |
ESTRASORB | Estradiol | Emulsion (topical) | 1.74g/pouch | 2 pouches once daily |
ESTROGEL | Estradiol | Gel (topical) | 1.25g/pump | 1 pump once daily |
EVAMIST | Estradiol | Spray (topical) | 1.53mg/spray | Initially 1 spray daily; may increase to 2–3 sprays if needed |
MENOSTAR | Estradiol | Patch (matrix) | 0.014mg/day | Once weekly |
VIVELLE | Estradiol | Patch (matrix) | 0.05, 0.1mg/day | Twice weekly |
VIVELLE-DOT | Estradiol | Patch (matrix) | 0.025, 0.0375, 0.05, 0.075, 0.1mg/day | Twice weekly |
ESTROGEN (VAGINAL) | ||||
ESTRING | Estradiol | Ring | 7.5micrograms/24hours | Once every 90 days |
FEMRING | Estradiol | Ring | 0.05mg/day, 0.1mg/day | Once every 3 months |
PREMARIN | Conj. estrogens | Cream | 0.625mg/g | As instructed |
VAGIFEM | Estradiol | Vaginal tablets | 10micrograms | Once daily for 2 weeks, then twice weekly |
PROGESTOGEN (ORAL) | ||||
AYGESTIN | Norethindrone acetate | Tablets | 5mg | Once daily |
PROMETRIUM | Progesterone (micronized) | Capsules | 100mg, 200mg, 300mg | Once daily |
PROVERA | MPA | Tablets | 2.5mg, 5mg, 10mg | Once daily |
ESTROGEN + PROGESTOGEN (ORAL) SEQUENTIAL FOR PERIMENOPAUSE | ||||
PREFEST | Estradiol (3 tabs); then estradiol + norgestimate (3 tabs) | Tablets | 1mg; then 1mg + 0.09mg | Once daily, sequentially |
PREMPHASE | Conj. estrogens (14 tabs); then conj. estrogens + MPA (14 tabs) | Tablets | 0.625mg; then 0.625mg + 5mg | Once daily, sequentially |
ESTROGEN + PROGESTOGEN (ORAL) CONTINUOUS COMBINED FOR POSTMENOPAUSE | ||||
ACTIVELLA | Estradiol + norethindrone acetate | Tablets | 0.5mg + 0.1mg; 1mg + 0.5mg | Once daily |
ANGELIQ | Estradiol + drospirenone | Tablets | 0.5mg + 0.25mg; 1mg + 0.5mg | Once daily |
FEMHRT | Norethindrone acetate + ethinyl estradiol | Tablets | 0.5mg + 2.5micrograms 1mg + 5micrograms |
Once daily, continuously Note: Progestin listed first |
PREMPRO | Conj. estrogens + MPA (28 tabs) | Tablets | 0.3mg + 1.5mg, 0.45mg + 1.5mg, 0.625mg + 2.5mg, 0.625mg + 5mg |
Once daily, continuously |
ESTROGEN + PROGESTOGEN (TRANSDERMAL) | ||||
CLIMARA PRO | Estradiol + levonorgestrel | Patch (matrix) | 0.045mg + 0.015mg/day | Once weekly |
COMBIPATCH | Estradiol + norethindrone acetate | Patch (matrix) | 0.05mg + 0.14mg/day 0.05mg + 0.25mg/day |
Twice weekly |
NOTES | ||||
This is not an inclusive list. Indications vary among products. For more information see the product listings in this section or contact the manufacturer. For combination products, the estrogen component is listed first. Strengths listed are not necessarily the same as the dosage. Frequency of dosing is that used for HRT; other uses may have other frequencies. Some products are given cyclically. 1Formerly piperazine estrone sulfate. Tablet strengths given as mg sodium estrone sulfate. Matrix patch: Estradiol is embedded in the adhesive layer that is applied directly to the skin. Reservoir patch: Estradiol is contained in a drug reservoir and its release is controlled by a copolymer membrane; contains more layers than matrix patch. MPA = medroxyprogesterone acetate. |