Hi. I took it when estrogen patch was increased. Had a lot of pms type symptoms- tender then sore breasts, bloating, spotting. Of course it could have been the increase of estrogen, but have increased this on different product and these symptoms didn't reappear. I also felt a bit euphoric whilst on provera (weird!) However, I would say that we are all different and we all have individual reactions to things, so what was my experience might not be yours! 🙂