Hi Linda, are you on the loading dose of every night for two weeks? I use ovestin and I got those side effects once I got past the loading dose side effects wore off, I also got burning when using it on the outside this also wore off as I got used to it, the fillers can irritate some ladies, vagifem has fillers also and caused horrible persistent burning for me,along with persistent stomach cramps, everyone is so different in how they react if you are early in the stages of using maybe give it time to settle, if you find the fillers are an issue in causing local irritation there's an estring that has no fillers that you could ask your gp for, if you are using the 0.01% cream which is weaker than ovestin but works the same way, the side effects will also wear off as you get used to it, hope you feel better soon,, take care x