I tried stopping sertaline once I was on HRT. The first time was an outright failure. I was a wreck. I restarted and things were good. Once I had more time on Hrt and that end of things seemed good, I felt overserved by sertraline. I tapered down and went off it again for several months. I just wasn’t myself. I don’t know if my brain chemistry has changed altogether since starting or what (if it even matters), but I’m just not myself off sertraline. I restarted but now only take 50mg, whereas I’d been on 75mg for about 5 years. The slightly lower dose feels better, as does less estrogen...when either of those things are too high for me, I feel edgy/irritable/angry/wired/generally unpleasant.