Hi!
Research indicates the absorption of micronized progesterone is enhanced twofold in the presence of food, a significant increase.
For a postmeno woman having difficulty achieving or maintaining hormonal balance, it wouldn't be surprising if a fluctuating progesterone dose was problematic. I wonder if it could also signal a drop to the body, resulting in spotting or bleeding.
Progesterone fluctuations affect the brain. The changes to cognitive function seem small in comparison to the more pronounced emotional changes. Some women seem especially sensitive and would want to ensure the most stable dose possible.
Progesterone also plays a role in carbohydrate, lipid and protein metabolism.
A few examples of progestone's role that might affect our sense of wellbeing.
Interesting question.