An update which could have something to do with absorption rate .... apparently there have been reports that some ladies have been having problems with Evorel patches since they changed manufacturer. I started feeling as if I wasn’t getting enough oestrogen earlier in the year then just ‘crashed’ like I wasn’t getting anything at all. It’s resulted in a dreadful depression and have been trying Estrogel along with Citalopram AD, but still not great. Am now thinking I would be better on pills, not my first choice but should absorb better. I don’t know about Sandrena, can you let me know if it improves your levels. Xx