It's been two weeks now.
Good:
I do feel like my hot flashes have reduced. They had already gotten significantly less frequent than the first few months after stopping birth control pills -- they were waking me up a couple of times a night then. So there was less room to improve, but I have noticed them less.
I'm single, so vaginal dryness isn't an issue that was affecting my life. However, I know that is a problem for many, and I can tell a significant difference after starting the HRT.
My acne has gotten better.
Neutral:
I don't feel markedly different either way.
Bad:
I've gained 5 pounds in the two weeks! If that keeps up at the same rate, I will likely go off HRT. I had managed to lose 20 pounds since stopping birth control pills, between a flare of my colitis and severe anxiety that kept my stomach in knots. Then I'd kept it steady for two months. I'm still overweight, and I don't want to gain back too much of what I lost.
I've noticed very little improvement in my muscle pain and stiffness, which was the main reason I went on HRT. (I have had MANY blood tests since January to try to suss out a cause, and nothing has turned up.)