With Estriol versus Ovestin, it depends how you react to each. I found Ovestin irritated, but am OK with Estriol externally, so it depends on the individual. If Vagifem didn't do anything for you, I think you should have been given Ovestin because it is stronger. Also, if the Vagifem wasn't working, why not do the loading dose anyway with one of the creams?
JP x