Hi
I managed to get some gel called OEstrodose from my local chemist through my GP as there is no evorel.
I am currently on 0.75microgrammes of evorel.
I was under the impression that 1 pump of gel equalled 0.25mg oestrogen, but I dunno if that is oestrogel rather than oestrodose, the one I have.
On my box it says the following
"this cannister delivers 64 meetered doses. Each metered dose 1.25g contains 0.75milligrammes of estradiol.
Does this mean that I only need one pump of oestrodose rather than 3 pumps like I thought I would need, as I thought I was getting oestrogel.
Thanks
EDIT I just read more of the box and it also says on the back oestrogel pump pack.
How come one metered dose equals 0.75microgrammes when I thought that 0.75 microgramme patch equals 3 pumps?
Thanks and sorry for the confusion.
Hi Dandelion,
One pump of Oestrogel has 0.75 mg or 750 µg of estradiol hemihydrate (dehydrated form).
One Evorel 75 patch has 4.8 mg of estradiol corresponding to a release rate of 75 µg of estradiol in 24 hours. The difference is that you have to use the gel daily and Evorel is applied twice weekly.
The pharmacokinetics of the gel is different from the patches, approximately only 10% of the estradiol in the gel is absorbed, hence the 10X difference in concentration of estradiol in the gel.
https://www.medicines.org.uk/emc/product/353/smpc'Pharmacokinetic properties
Absorption
Pharmacokinetic studies indicate that, when applied topically to a large area of skin in a volatile solvent, approximately 10% of the oestradiol is percutaneously absorbed into the vascular system, regardless of the age of the patient.
Distribution
Daily application of 2.5 g or 5 g Oestrogel over a surface area of 400-750 cm2 results in a gradual increase in oestrogen blood levels to steady state after approximately 3-5 days and provides circulating levels of both oestradiol and estrone equivalent in absolute concentrations and in their respective ratio to those obtained during the early-mid follicular phase of the menstrual cycle.
Oestrogel was administered to 17 postmenopausal women once daily on the posterior surface of one arm from wrist to shoulder for 14 consecutive days.
Maximum serum concentrations (Cmax) of oestradiol and estrone on Day 12 were 117 pg/ml and 128 pg/ml, respectively.
The time-averaged serum oestradiol and estrone concentrations (Caverage) over the 24hour dose interval after administration of 2.5 g of Oestrogel on Day 12 were 76.8 pg/ml and 95.7 pg/ml, respectively.
Biotransformation
Metabolism of oestradiol takes place mainly in the liver under oestriol, estrone and their conjugated metabolites (glucuronides, sulphates). These metabolites also undergo enterohepatic recirculation.
When treatment is stopped, oestradiol and urinary conjugated oestradiol concentrations return to baseline in about 76 hours.
Elimination
Oestriol is the major urinary oestradiol metabolite. However, glucuronide and sulphate metabolites of oestradiol and oestrone are also found in urine and bile. Metabolites excreted in bile undergo enterohepatic recirculation or are excreted in the faeces.'
Hope this helps,
BeaR.