I am on Evorel Sequi (have been for last month) after changing from Evorel Conti and before that Evorel 50. This morning I feel like I have been run over by a bus - horrible stiff neck, crawling sensation across my head, painful back, headache, felt nauseous during the night, anxiety......I'm guessing this is due to the hormones during the second half of the cycle on Sequi. Although HRT has helped with feeling hot during the night and mood swings, I feel the minuses outweigh the pluses and I'm now done with HRT. I will try the natural remedy route, soya etc. and see how I get on. I am 53 - anyone else had these same symptoms on Evorel Sequi and can give me any advice? Thanks ladies!