Agreed I used the serenity cream for at least 6 months absolutely no results with it save your money.ive just started the patches and I'm hoping I'll have No skin issues with the adhesive I'm due to do my first removal today but so far so good though I slept like a baby the first night I applied it,I was nervous about changing over from the Premarin tabs but shouldn't have worried so much and of course the patches are safer for me.good luck with whatever you decide to do but I don't recommend serenity.xx