hello all, I haven't posted for a long time so wanted to give an update. I'm now on estradot 50 (up from 37) and utrogestan 200mg, taken 12-14 days of the month. On the plus side, I no longer get hot flushes, I sleep fine (thank god!), and the brain fog has gone. The depression though still comes and goes. I've decreased sertraline to 25mg a day; it's hardly worth taking it, I know, but the few times I've stopped I've plunged into the black fog again so I'm sticking with it. Things are definitely better than they were a few months ago, so I think I'll stick with this regime for a while. Though I may start taking progesterone vaginally, because the one thing I dislike about it is the overwhelming fatigue. I'm very active, running and training four to five times a week, but sometimes I feel like I could stay in bed all day. I'd also like some libido back: when I cut sertraline (slowly) down from 150mg to 25mg, it did come back but now it seems to have gone again. And I feel like I'm gaining weight around my belly which makes me feel heavy and sluggish. Oh well. We are but human experiments, aren't we? Anyway thanks for your help and advice. Things aren't perfect, but they are better, for now. Hope you're all doing OK.