Hi Brit66, I think that's another potentially dangerous generalisation. Cassie is on a very low dose of the gel. If a woman reads she doesn't need to wash her hands after applying the gel and she's on 4 or more pumps, the amount of estradiol after doing this daily for many years would not be comparable to Cassie's personal experience.
Personal experience is invaluable but should never replace medical instructions based on studies, after all we're all different.