Hi, my doctor asked me to look at this site to see if it will help me, so here goes. I took Prempak C for 7 yrs and was happy. At age 51 I wanted to change it to the one where you didn't have a monthly break but I kept panicking over the amount of bleeding I was experiencing. At the time my doctor didn't tell me that, had I stuck with the new HRT, the bleeding would have eventually stopped. Instead, he asked me if I wanted to go back on Prempak C or nothing. I chose nothing, having no idea what I was letting myself in for. Fourteen yrs later, now aged 65, I am still having hot flushes with excessive sweating day and night. I wake up at least four times every night hot and sweating. I don't know what it is like to have a good night's sleep. During the day, just before I break out in a sweat, I have a deep dip in my mood. It's almost like a panicky despair. Fortunately, it only lasts for a minute. Once I've stopped sweating my mood goes back to normal. It's so disconcerting experiencing this endless times a day. I also have a great deal of muscle fatigue which I believe is connected to my body's inability to adjust to a normal post menopausal condition. I know several women suffering from a kick-back for this length of time after taking HRT. All my family and friends in my age group, who didn't take HRT, have past the menopause stage and are leading normal lives.