Hi everyone, It's a while ago since I last posted. I'm feeling really depressed I've been on Gynest cream, Evoril Conti patches, Vagifem and now I'm on Premique low dose tablets for vaginal atrophy. I'm aching all over, have no energy, I feel foggy in my head if you know what I mean. To be honest I feel so depressed with all this. I'm still not doing too well down below either. I'ts very sore and uncomfortable and when I wee it hurts like mad. Does anyone know how long it will be before these Premique tablets should start to be effective and could I use Gynest cream on the outside whilst taking Premique or would that be quite dangerous to do this, could I be getting too much estrogen. I'm not sure if it's these tablets that are making me depressed but keep thinking that it's too soon for it to be these because I have been on them only a fortnight.