Hi kittydaydream
High oestrogen is not likely to cause fatigue and anxiety - it is an energising hormone and should lift mood. Could there be another reason for your fatigue? Virus? Vitamin or mineral insufficiencies? Thyroid problems? If you are peri-menopausal maybe your own cycle is kicking in?
Depending on the symptoms that led you to start HRT - if you had flushes and sweats for example - if these have been banished by the patch then your oestrogen is unlikely to be far too low, though sometimes the minimum dose needed to eliminate these obvious symptoms is not necessarily the best "feel good" dose and some women require more than the minimum to feel at their best. Nevertheless 100 mcg is quite a high dose, notionally and would be surprising eg if you were not absorbing a relatively decent amount ( whatever that might be?!).
Also depends how long you have been on this particular regime, and how long you've been taking HRT in general as well as where you are in menopause, all of which will have some bearing on how you feel at any given time.
Hopefully it's just a blip and you will improve soon
![Smiley :)](https://www.menopausematters.co.uk/forum/Smileys/extended/smiley.gif)
Hurdity x