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Author Topic: Progesterone intolerance  (Read 627 times)

Helenmelon1974

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Progesterone intolerance
« on: July 03, 2024, 07:13:20 AM »

Hi ladies, I’m quite new to all this HRT stuff and just wanted to ask peoples experience of using Utrogestan vaginally (100mg daily) if they’ve had intolerance reactions to other forms of progesterone? I’ve tried Evorel Conti and the Mirena and have suffered awful anxiety and depression on both.

I’ve been given Evorel 50 and Utrogestan (GP has given this to take orally but my intention is to use vaginally) but now I’m anxious about starting again and wondering if I should just go without HRT altogether!

I’m currently using Vagifem 10mg for reoccurring UTIs.
« Last Edit: July 03, 2024, 07:48:08 AM by Helenmelon1974 »
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sheila99

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Re: Progesterone intolerance
« Reply #1 on: July 03, 2024, 07:42:31 AM »

You can't go without unless you either stop oestrogen or have a hysterectomy. I think you'll have to try it to see. I get fatigue on it vaginally but not anxiety or depression. My anxiety was oestrogen deficiency. It's body identical so on theory at least it should be better.
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Helenmelon1974

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Re: Progesterone intolerance
« Reply #2 on: July 03, 2024, 07:47:45 AM »

I meant go without HRT, sorry 🙈
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CarolineM

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Re: Progesterone intolerance
« Reply #3 on: July 03, 2024, 10:18:01 AM »

People on here seem to have such different reactions, I think the only way you'll know is to try and see. 

I seem to have settled on a mixture of oral and vaginal for Utrogestan, that seems to work best for me.

I was scared to death before taking it, so I can understand you hesitating.

Good luck!
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sheila99

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Re: Progesterone intolerance
« Reply #4 on: July 03, 2024, 10:27:06 AM »

I meant go without HRT, sorry 🙈
Must admit I was surprised at the question, I thought you'd already have known  ;D
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Helenmelon1974

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Re: Progesterone intolerance
« Reply #5 on: July 03, 2024, 04:01:47 PM »

People on here seem to have such different reactions, I think the only way you'll know is to try and see. 

I seem to have settled on a mixture of oral and vaginal for Utrogestan, that seems to work best for me.


I was scared to death before taking it, so I can understand you hesitating.

Good luck!

Thank you for your reply. I keep reading posts about women having to chop and change and tweak for months/years and still getting nowhere and it’s really putting me off the whole idea of HRT!

On the other hand I want some energy and motivation back and not to be so up and down mood wise! I’ve started making a real effort with my diet as I need to lose weight and trying to be more active so maybe that alone will help. I lost my partner last year under very traumatic circumstances and I’m just trying to rebuild my life again I suppose. Not sure why to do for the best. 😕

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bombsh3ll

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Re: Progesterone intolerance
« Reply #6 on: July 03, 2024, 04:13:42 PM »

I'm sorry you're having treatment difficulties at the same time as dealing with bereavement, that must make things really tough.

What I would say is you have nothing to lose by trying the vaginal micronised progesterone.

The previous progestins you have tried were synthetic, and whilst they are fine for many women some just can't get on with them yet find the body identical progesterone much kinder.

Even if you don't feel massively better on hormone therapy, it's also about the hip fracture or the urinary sepsis that you DON'T get 10 or 20 years from now.

The energy, mood and motivation symptoms you mention are often related to low testosterone so that might be worth looking into as well if you don't get the results you want on estrogen and progesterone.
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Helenmelon1974

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Re: Progesterone intolerance
« Reply #7 on: July 03, 2024, 06:57:22 PM »

I'm sorry you're having treatment difficulties at the same time as dealing with bereavement, that must make things really tough.

What I would say is you have nothing to lose by trying the vaginal micronised progesterone.

The previous progestins you have tried were synthetic, and whilst they are fine for many women some just can't get on with them yet find the body identical progesterone much kinder.

Even if you don't feel massively better on hormone therapy, it's also about the hip fracture or the urinary sepsis that you DON'T get 10 or 20 years from now.

The energy, mood and motivation symptoms you mention are often related to low testosterone so that might be worth looking into as well if you don't get the results you want on estrogen and progesterone.

Thank you again for your reply I really appreciate it. I will just go for it! I’ve got diazepam if the anxiety does kick in.

My other questions (sorry 🙈) are, do I carry on if it causes me issues and hope they go? Is it likely to settle? I have asked my GP for 3 monthly Utrogestan but she says she can’t agree to that and has emailed gynae to ask them but has no idea how long it will take for them to get back to her.

Regarding the testosterone, will GPs prescribe that or is it done through referrals? I’m happy to pay for a private blood test as I’ve seen that’s what most people seem to have to do.

It’s just a minefield 💣🤣

Thank you again x
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Hurdity

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Re: Progesterone intolerance
« Reply #8 on: July 03, 2024, 07:40:35 PM »

Hi Helenmelon

Sorry to hear about losing your partner.

Re HRT - try not to be anxious nor read about problems that others have had. I have hardly had to do any tweaking and have been on HRT since I was about 54, now 71. Mostly on the same regime which has been oestrogen patches and vaginal utrogestan (though initially cyclogest off-licence, before Utrogestan was available). However I have almost always taken it on a cycle and wouldn't relish the thought of DAILY vaginal oestrogen. I do find it irritates my bladder when I am on that phase of the cycle - eg getting up for night time pee, as well as some irritation of labia (I do use vaginal oestrogen too - vagirux and estriol 0.01%).

I would be interested to hear of women on here who are taking it daily, vaginally.

Previously for a very short time I used Evorel conti but gave me headaches. Utrogestan is bio-identical, yes but is taken in larger doses than the synthetic progestogens so is not without side effects - so do be prepared for these - though do not worry! Progesterone is a sedative so you may feel tired, but you may well find 200 mg is tolerable. Many women take 100 mg daily orally without issues.

As for giving up HRT - you haven't said your age nor menopausal stage but I'm guessing from your name you may be 49 or 50? That being the case - you would be too young in my view not to think about HRT, as you are still not at the avergae age of natural menopause in the West (51/52) and even so we may live to our 90's so that's a long time to be in an oestrogen deficient state!

Some GPs maybe prescribe testosterone but as it's off-licence ( there are no licenced UK testosterone preparations for women so we have to have T products made for men which are stronger) they may not. The NICE Guidelines made provision for T prescription in cases of low libido when on adequate HRT - (but oral HRT also affects - can reduce libido/response) but it is really up to the GP/practice.

I had to see a private specialist initially in 2015 - but this was before the NICE Guidelines, but thereafter my very enlightened gynae specialist GP agreed to continue prescribing it and it has been on my repeats since then. You shouldn't need a blood test although a baseline test is helpful. T tests are inaccurate at very low levels as the tests are designed for the T ranges experienced by men so not sensitive enough for women - though they are the best we have!

Hope this helps

Hurdity x
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Helenmelon1974

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Re: Progesterone intolerance
« Reply #9 on: July 03, 2024, 08:50:42 PM »

Thank you so much for all the information Hurdity. Yes I was 50 last week, still in shock about that tbh 🤣 I’m just going to bite the bullet and start the HRT.

I’ve no idea whether I’m peri or post but looking back I’ve had symptoms for around 7 years when I was put on ADs for anxiety. I had the Mirena removed after 6 years in February which caused a bleed, had another put it in April which I reacted badly to and had to be removed after 10 days which also caused a bleed but other than that no periods. Although the GP had prescribed 100mg daily of Ustrogen along with the Evorel 50 I think I’m going to try it sequentially to begin with and see how I go. The Evorel patch is now on! 🤞🏻

I do want to be on HRT because I read so many stories about women who ‘get themselves back’ and I want that. The up and down moods, anxiety, insomnia, lack of motivation and focus, forgetfulness, brain fog etc are not fun and I miss me!

Helen x
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Ebonybones

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Re: Progesterone intolerance
« Reply #10 on: July 03, 2024, 10:53:16 PM »

I started Utrogestan 5 weeks ago and have felt sick every since then I had diarrhoea 10 days after starting and the last two days  :o

I’m not sure if it agrees with me but I don’t want to stop it as it’s working

I’m hoping it calms down once my body gets used to it
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Helenmelon1974

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Re: Progesterone intolerance
« Reply #11 on: July 04, 2024, 02:38:51 AM »

I started Utrogestan 5 weeks ago and have felt sick every since then I had diarrhoea 10 days after starting and the last two days  :o

I’m not sure if it agrees with me but I don’t want to stop it as it’s working

I’m hoping it calms down once my body gets used to it

Sorry to hear that, are you taking it orally?
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Ebonybones

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Re: Progesterone intolerance
« Reply #12 on: July 04, 2024, 10:59:01 AM »

Yes I am
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Penguin

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Re: Progesterone intolerance
« Reply #13 on: July 04, 2024, 11:03:35 AM »

Yes I am

As a previous user of utrogrstan (cyclical on days 15-26) may I suggest trying it vaginally? That means it doesn't go through digestive system and avoids the nausea / stomach side effects. While not licensed in UK for vaginal, it is in many other countries, including Australia where I was prescribed it.
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Ebonybones

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Re: Progesterone intolerance
« Reply #14 on: July 04, 2024, 08:59:00 PM »

Would I need to adjust the dose? I’m not 100% sure it is the Utro but I’ve been feeling sick a few days after I started it so assuming
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