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Author Topic: Good estrogen levels?  (Read 1245 times)

JoannFran

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Good estrogen levels?
« on: March 25, 2024, 01:27:41 PM »

Hi everyone

Does anyone know what an optimum estrogen level should be?  I know this probably varies person to person and we should go on symptom control, but I was sure my estrogen was too high (I'm on 100mg patches) and yet it came back at 269.  I was thinking of reducing to 75 patches but my meno dr says that it's not too high.  I'm now wondering if my anxiety symptoms are because it's not high enough?

Any advice would be greatly appreciated.  There's such a minefield of information on the internet and no real definitive answer.

Thanks ladies! xx
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seemster

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Re: Good estrogen levels?
« Reply #1 on: March 26, 2024, 10:18:14 PM »

Hi there - that oestrogen level certainly isn’t too high although if you are peri then don’t forget your own hormones re fluctuating a lot as well.

I guess you might benefit from an increase in oestrogen but if the only symptom that isn’t being controlled currently is anxiety then I’d suggest something else that is more targeted... I’ve personally found a huge benefit from taking magnesium bisglycinate - far less anxiety and also better quality sleep.

Good luck!
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Hollyboll

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Re: Good estrogen levels?
« Reply #2 on: March 27, 2024, 08:12:01 AM »

If you’re still in peri it will likely fluctuate so probably best not make decisions from one test. Also, for some people the patches release less by day 3/4 so worth checking that.

But that level is not too high and if consistently low yes cd be reason for anx. I agree other things might help but so might different HRT. That’s a pretty low level for 100 patches so might be absorption, or last day etc. 

It does vary wildly and there are much more knowledgeable here than iso hopefully someone else can contribute re levels.

Hth x

« Last Edit: March 27, 2024, 09:01:48 AM by Hollyboll »
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sheila99

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Re: Good estrogen levels?
« Reply #3 on: March 27, 2024, 10:07:41 AM »

How quickly did you increase? Anxiety can be a symptom of too much but also too little oestrogen. If you started low and increased slowly you can probably rule out too much oestrogen but if you increased quickly it could be either. You levels aren't high but as you point out the level each person feels good at is different.
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joziel

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Re: Good estrogen levels?
« Reply #4 on: March 27, 2024, 10:14:05 AM »

Whilst you will now get loads of people telling you that estrogen levels fluctuate during peri, what people don't seem to realise is that your own estrogen is only going to ADD to any amount from HRT.

Therefore if you have 269, your own body might be contributing some of that and the amount you are getting from HRT could be even lower.

What day of your cycle did you do the test? It's best to do it during your period when your own estrogen is lowest so you get a sense of what you are getting from HRT.

The three different Newson menopause doctors I've seen have all said that most people need their estrogen between 400-600pmol for best symptom relief during peri. I'm now on 9 pumps of Oestrogel, which is over 200mcg of patches. This is giving me about 430pmol serum estradiol. You need to forget about the licensed dose and focus on what your serum levels are. And it's worth trying getting the dose up to 400-600 just so you know if this helps. If it doesn't you can reduce again. Personally, I only started to sleep again when I got to 8 pumps of gel (200mcg patches equivalent).
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JoannFran

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Re: Good estrogen levels?
« Reply #5 on: March 27, 2024, 03:24:06 PM »

Thank you for your replies. 

Joziel - thank you, I just had an aha moment, because I totally forgot to factor in that the 269 would INCLUDE my own estrogen (duh).  So actually I'm probably not getting enough from the HRT.  I'm on 100 patches but meno specialist has said to go up to 100 patch + 25 patch.  The bloods were taken on day 22. (when my own estrogen should be higher or just starting to drop, so actually again that tells me that I may need more from the HRT).  I wish I got hot flushes or night sweats as that would at least be a good indicator, but I've never had those.  xDo you mind me asking what progesterone you take and if you take a higher amount?  My meno dr has said that the 200mg for 14 days is still enough.  I'm not great on the utrogestan, definitely lowers my mood but nothing extreme and I can cope with it only being 14 days.

My main symptom is anxiety (which I never had before peri) and horrible heart PVCs and weird head pressure sensations.  I'm on day 1 of cycle now and all the symptoms are bad (along with smelling cigarette smoke) so again that tells me that I probably need more estrogen.  I've always made any increases very slowly (currently cutting the 25 patch in half but think I might just bite the bullet and put the 25 on next change day).  I guess the only way I'm going to know is by trying it.

I'm doing everything I can to help the anxiety, I take propranolol, Magnesium, I exercise daily, I eat well, I've cut out sugar, caffeine and alcohol, I have CBT.  I'm not sure what else I can do as it's not like a mental anxiety is more like a physical feeling of anxiety  :(

Thanks again for all the replies and help - much appreciated x
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Hollyboll

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Re: Good estrogen levels?
« Reply #6 on: March 27, 2024, 07:12:03 PM »

Whilst you will now get loads of people telling you that estrogen levels fluctuate during peri, what people don't seem to realise is that your own estrogen is only going to ADD to any amount from HRT.

Therefore if you have 269, your own body might be contributing some of that and the amount you are getting from HRT could be even lower. ...

The three different Newson menopause doctors I've seen have all said that most people need their estrogen between 400-600pmol for best symptom relief during peri. I'm now on 9 pumps of Oestrogel, which is over 200mcg of patches. This is giving me about 430pmol serum estradiol. You need to forget about the licensed dose and focus on what your serum levels are. And it's worth trying getting the dose up to 400-600 just so you know if this helps. If it doesn't you can reduce again. Personally, I only started to sleep again when I got to 8 pumps of gel (200mcg patches equivalent).

I do realise this actually ;), but it still means you are getting fluctuations.  And what I've learned the very hard way is that increasing oestrogen levels increases the fluctuations because it increases the peak and therefore the drops.  THis is directly opposite from what Newson told me when they pushed up my oestrogen levels (which was more in there made it more undulating).  Everyone at
Newson (whom I saw first and about whom I was evangelical for ages - recommended to many many people) is all about increasing oestrogen.  I only ended up elsewhere for a random reason & had every intention then of going back to Newson.  But i've now learned The BMS became so worried about NH approach that they issued a statement (Dec 22) warning about high levels. Newson says 'BMS can't tell us what to do'.
I was put way beyond 200 by them, and it made me very (very) ill indeed - including anxiety like I couldn't open front door let alone leave through it.  I have now been incredibly lucky to see an actual leading meno consultant, and the difference in advice/approach is staggering. 

ANYWAY JoannFran that's all to say I'm so sorry you're having horrid anxiety.  Your levels are nowhere near dangerously high and probably could go up a bit, so good plan to increase - by 12.5 or 25 but body needs a good couple of weeks each time to settle so good to do it slowly.  Might be worth you changing patches every 3 days (but check this with your specialist as I'm on conti, no idea really how cycl works).  And in terms of checking your blood levels it's worth doing it on same 'change' day (I was recommended about 12 hours after change so perhaps morning after night change).

If once you have another test(s) and over 100 your levels are still low, if you're still getting such bad symptoms, might be worth trying a different kind of HRT.  Do you rate  your meno dr?   My own experience is they vary a LOT - if your GP is co-operative it may be worth trying to get a referral to a meno clinic / consultant ... with those levels on 100 dose and still getting symptoms it should be OK if GP any good.  The waiting lists are long but good to get into the system ...

HTH xx

« Last Edit: March 27, 2024, 07:34:21 PM by Hollyboll »
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JoannFran

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Re: Good estrogen levels?
« Reply #7 on: March 27, 2024, 08:13:33 PM »

Hi Hollyboll - Thank you for your advice.  Do you mind me asking which meno consultant you have seen? (I have been thinking of seeing someone else and money isn't really an issue).  I do like my dr (she is my GP and specialises in menopause) but I do feel like her approach is also throw more estrogen at it.  And also offering me antidepressants or beta blockers, which I know she's trying to be helpful but I never had this anxiety before peri, so something must be causing it and it's driving me absolutely insane trying to get to the bottom of it!  I was wondering if I 'may' be estrogen dominant as I have breast and ovary cysts, but then the blood results confused me as I was expecting them to be much higher so now I'm wondering if it's low estrogen.  I haven't had any of the 'tell-tale' hot flushes or night sweats.   How did you figure out that high estrogen was causing your anxiety?  Are you still on HRT?  I have tried estrogel but that makes me very wired and jittery.  It's all so confusing isn't it.  I WILL get to the bottom of it though because I am not prepared to spend the rest of my life feeling like this, which sounds dramatic but is true.  I am a shadow of the person I was 4 years ago.  Anyway, thanks for taking the time to reply xx
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Mary G

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Re: Good estrogen levels?
« Reply #8 on: March 27, 2024, 08:49:17 PM »

That is a good level of oestrogen for someone who is post menopause and needs a maintenance dose to keep symptoms at bay.  As others have said, it might not be enough for women in peri menopausal with spiking oestrogen levels in which case, you would probably need to be somewhere in the 4-500s to flatten the spikes.

I doubt that level of oestrogen would be enough to cause anxiety. 
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Hollyboll

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Re: Good estrogen levels?
« Reply #9 on: March 27, 2024, 09:36:20 PM »

Hiya JoannFran

No worries - I found this board belatedly and found it enormously reassuring and helpful even just to know it isn't just me.  I completely get it - and doesn't sound dramatic to me! - I have lost almost everything in the last 4-5 years of this sh&tshow, total shadow of former self/life, and reached the point that I simply could not carry on like this.  Oh - and I never had a single hot flush or night sweat in in the years before HRT (GP was old skool), or on the first year, or in fact until my levels started with crazy spiking more recently ...

... which was one of the ways I (or rather the consultant) figured out high levels caused tachyphylaxis ie switched off receptors so it's like having zero oestrogen.  I absolutely am still on HRT - consultant has been very clear that I'm a 'challenging' case but is determined to sort it and (having considered it before dismissing it) that things would be worse off HRT. 

Everyone is so different.  I think unfortunately the amazing and in many ways excellent awareness-raising of the last few years has brought with it a slight message of 'peri/meno = hard; then take HRT; all sorted and magic; simples" and it's obviously very absolutely not like that.  I fell into that trap, and trusted I was getting the best advice from a leading campaigner/GP who specialises in menopause.  But knowing what i know now, I feel stupid for trusting that  ... I can't think of another area of medicine where any of us would equate a GP with a consultant ... unfortunately the bar is so low for GPs re: meno that someone who does an online course or reads around a bit suddenly 'specialises' in menopause ... .. no GP has the same knowledge and training and expertise as a consultant, or seen the same number of cases. 

Anyway - I've DM'd you.  xx
« Last Edit: March 27, 2024, 11:14:37 PM by Hollyboll »
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joziel

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Re: Good estrogen levels?
« Reply #10 on: March 29, 2024, 10:00:56 AM »

I don't know how to do the fancy quotey thing, but have to rely on copy and paste  ;D

"And what I've learned the very hard way is that increasing oestrogen levels increases the fluctuations because it increases the peak and therefore the drops."

Can you explain how that is? Sorry, I just can't imagine it. If you are adding a stable estrogen dose in each day, then any fluctuations from your own body are reduced. I can't understand how the thing you're describing 'increases the peak and therefore the drops'. The estrogen you take doesn't fluctuate like the estrogen from your body. If you take 400pmol of exogenous estrogen and your body is sometimes spurting out 50 and sometimes spurting out 300, then sometimes you will have 450 and sometimes you will have 700 - but you will never have less than 400. Because that's the baseline decided by the exogenous estrogen.

"THis is directly opposite from what Newson told me when they pushed up my oestrogen levels (which was more in there made it more undulating).  Everyone at
Newson (whom I saw first and about whom I was evangelical for ages - recommended to many many people) is all about increasing oestrogen."

That hasn't been my experience. When I first started there, they were very concerned about my initial reaction to HRT and my then doctor told me to slice up patches and very gradually titrate until my symptoms resolved. I never reached the point where my symptoms resolved, so then I was told to stop all HRT and see what that was like (since these particular symptoms had begun after starting it). I did - and 5 months later I still had these symptoms. Having ruled out stopping estrogen and a low to medium dose of estrogen, it then was decided to go the other direction and stabilise me on quite a high level. I'm now on 9 pumps of gel - which is only taking me to around 430pmol - and sleeping the best I have in the last 2 years.

I haven't heard anyone at Newson want to increase estrogen for the sake of it, it's about increasing it to the point that symptoms resolve or at least trialling a higher dose to see if that happens. Seeing these things are not about the amount of estrogen you take but about your serum levels it makes zero sense to focus on doses.

"But i've now learned The BMS became so worried about NH approach that they issued a statement (Dec 22) warning about high levels."

You do know the BMS are ridiculously conservative and would still be singing from the WHI hymn sheet if it weren't for pressure to get with it from the likes of Newson, Davina etc? Personally I wouldn't be worried at all by any statements the BMS offer. They have clinicians still saying 'take the least amount for the shortest time' crap.... Their warning about doses is a case in point. Some people have 430pmol from 2 pumps of gel. I have 430pmol from 9 pumps of gel. The dose itself is irrelevant.

"I was put way beyond 200 by them, and it made me very (very) ill indeed"

Unfortunate, but at least you got a chance to try a higher dose and to see what it did. Had you never been allowed to try it, you would never have known. I have a friend (not with Newson but with another private menopause clinic) who needs her estrogen to be 1300pmol to be symptom-free. What Newson DOES say, is that this should be an individualised process where everyone should have the right to access the hormones they need to feel better.

Just because being put 'way beyond 200' made you ill, doesn't mean that the same is true for every woman. Personally, I need to be over 400 to be symptom-free and to sleep. I would not want the right to be well to be taken away from me because you personally tried over 200 and it made you feel ill.

It's all trial and error until you find what works. You need the right to 'trial' the dosage you need. And there will always be more 'errors' before you find what works. That's not the fault of the clinician. It's part of the process.
« Last Edit: March 29, 2024, 10:11:47 AM by joziel »
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Mary G

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Re: Good estrogen levels?
« Reply #11 on: March 29, 2024, 12:00:14 PM »

You do know the BMS are ridiculously conservative and would still be singing from the WHI hymn sheet if it weren't for pressure to get with it from the likes of Newson, Davina etc? Personally I wouldn't be worried at all by any statements the BMS offer. They have clinicians still saying 'take the least amount for the shortest time' crap.... Their warning about doses is a case in point. Some people have 430pmol from 2 pumps of gel. I have 430pmol from 9 pumps of gel. The dose itself is irrelevant.


You can say that again.  They seem to get their knickers in a twist about compounded hormones too despite knowing that they are a last resort for women who are desperate to find a form of progesterone to enable them to continue with HRT.  They try to scare women into not taking compounded hormones by suggesting they are unsafe because they are unregulated but they completely ignore the fact that progesterone is as effective and safe as your womb lining says it is and it should not be decided by somebody sitting behind and desk with no access to the woman's scans.  Ditto women who take a lower dose of branded progesterone.  They are completely inflexible.

Surprisingly, the BMS do not insist on regular transvaginal scans for women on HRT and that is unsafe.  They have absolutely nothing constructive to say about progesterone intolerance and will not even sanction lower progesterone doses backed up with scans. 

I can only assume the Newson clinic came under pressure from them.

I don't know if this is in any way connected to the BMS but from what I have read on here, the latest thing seems to be scaring women half to death with badly organised and unnecessary hysteroscopies.
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