I have been on Vagifem for several years. In September my prescription was changed and I ended up with the ones with reusable applicator and have struggled to keep the VA under control. I asked to have my prescription changed back to Vagifem and now have flare up under control. I was getting a residue discharge from the reusable applicator ones and that was irritating the vulval skin, something I have never had with Vagifem.