I had it. I was 63, no HRT before. My spotting was after 3 months. I was advised to stop, given an examination and had an ultrasound, all was well but it frightened me so I didn't use it again for another year, managed with replens but then the VA had worsened withouttreatmentso i tried again, the second time i got breast pain then recently i had a bit of blood so another exam and ultrasound, again all well. I've increased the dose and I'm ok, no side effects. The problem with VA treatment when you're aging is the VA increases and the original dose isn't always enough, you're fighting back the tide.