It sounds like you've thrown everything at it this time. With thrush you do feel worse before you get better, literally. When the candida cells die they release a toxin that causes flu like symptoms and other aching in the body, it's called candida die off. If you've been feeling awful it could be this and at least you know it's worked. Fluconazole is a very strong medication and also has it's own nasty side effects so it's no wonder we feel ill, it's not just the thrush. You should start to feel better again in a couple of days after your last dose.
With the estrogen you take doubling up might be a bit too much cream and it's just going to ouze out anyway, but carry on using everyday and perhaps a good moisturiser in the moring to soothe everything.
I couldn't tolerate the Caneston cream it burnt too much.