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[Oliversut01]

Can I ask, has anyone been diagnosed with LCIS following a breast biopsy and stayed on HRT? I haven’t been told to come off it but now very wary that it may cause something more serious - any feedback would be appreciated.

[CLKD]

LCIS being ??

[Ana21]

Hi Oliversut01 and CLKD,

"Lobular carcinoma in situ (LCIS) is an area (or areas) of abnormal cell growth that occurs in the lobules of the breast that increases an individual's risk of developing invasive breast cancer. Lobules are the milk-producing glands at the end of breast ducts. Individuals diagnosed with LCIS tend to have more than one lobule affected.

LCIS is not a true breast cancer but an indication that an individual is at higher-than-average risk for developing an invasive breast cancer at some point in the future."

"LCIS is usually hormone receptor-positive, meaning that estrogen and/or progesterone fuels the growth of the abnormal cells."

Anti-estrogens are used as prophylactic treatment.

Read more here:
https://news.cancerconnect.com/breast-cancer/lobular-carcinoma-in-situ-an-overview

"Duration of EPT (estrogen plus progestin therapy) use was linked to excess BC risk overall and to ductal and lobular cancer in situ"

Read more here:
https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-020-01365-9