I can't find my post on here from a few days ago where I was asking for advice on why I suddenly felt horrendous on "good" (new estradot patch) days. I figured it out. I hadn't been sleeping well so was taking melatonin for several days. There's no established clinical link between melatonin and next-day depression, but it is known that it blocks dopamine. And there is plenty of anecdotal evidence from people who say it makes them feel appallingly low the next day. It me.
So I stopped taking it, sprayed myself liberally with magnesium at night instead, and I haven't had those horrendous days since. The day after I stopped I could feel the difference. Like I wasn't being poisoned. Now, I'm back to the usual coasting on the surface. Not happy, not abysmal.
Slightly fatigued though by how sensitive my brain has become to everything. I can't drink alcohol any more, I definitely can't take anti-histamine sleeping pills, and now no melatonin either.