It was crippling muscle spasms and anxiety and jitters (which I'd never had before) that finally made me try HRT. 4 pumps helped both those main symptoms go away but anxiety would creep back from time to time. Anxiety was back again with a vengeance and horrendous around Christmas (had family caring stuff going on too) along with the worst palpitations so i reduced to 3 pumps and it all settled. But then the sore large boobs and bloating kicked in after 3 months, so reduced it again. But by too much maybe? My gut feel is that lower oestrogen is better for me for most of my other symptoms (allergies, anxiety, palpitations) if only I could feel happier, less irritable and less angry. I have a good life and no worries at all (except very ill/ageing parents) and yet, despite wanting to make the most of it, I'm not at the moment. Im sure like everything else it will pass, it just seems to be taking a long time!