I indeed did have thrush again. The Doctor prescribed another fluconazole and Canesten external cream. She said if it didn’t clear this time, she would prescribe a two month course of fluconazole one per week. She did believe the ache was due to me lacking greatly in Oestrogen. I have to do a two week loading dose of estriol cream, then twice a week.Previously, I couldn’t use estriol internally as it burnt so much, not a problem now, so I’ll take that as being good. My ache hasn’t gone completely but isn’t so prevalent. Have had several hours without the ache. Have had visitors last few days and have been doing quite a bit of sitting (not pleasant) even with my special cushion. Suffering today. Asked the Doctor on Friday, (another lady Doctor) if I should take in another swab to see if previous thrush treatment had worked, she said yes. She also said the estriol cream hadn’t had time to work yet been using for 10 days. I realised it was too soon. I know I need to be more patient, but that is easier said than done. Roughly how long did it take for estriol cream to work for you? Replies as always appreciated.