Just a reminder in this hot weather to keep estrogen cream in the fridge during the daytime as it will degrade in temperatures above 25° and not work as well. Vagifem can't be refrigerated but keep in a cool place too.
Update:
Found this on a Vagifem questions and answer page.
You should always keep Vagifem® 10 mcg out of the reach of children. Store at 77°F (25°C). It’s okay for Vagifem® to get as cool as 59°F (15°C) or as warm as 86°F (30°C). Do not refrigerate.
Not sure what happens to it above or below these temperatures. I had a box that was about a year old, still well in date as the shelf life is 3 years, it had been in the wardrobe during last years heatwave.
I used a few but the pessary burned each time when applied and when I took the pessary out the burning stopped. I threw them away and opened a new box that was fine and no burning. Maybe something degrades in the fillers that caused the irritation. Don't mistake this for atrophy burning.