CLKD no, but with the citalopram there were brands that were literally less effective than others, like I'd taken less of the drug if that makes sense. I do know fillers can be an issue as well, especially if people are intolerant to certain things but that wasn't the issue I had. The pharmacist just said that he'd heard of it happening and his suggestion was to just block me from being given the ones I had that experience with. It shouldn't happen given all the tests they have to go through.