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[floraljo]

Hi,
I'm 41, on hrt. My SHBG blood tests have been high before and since taking HRT. GP does not know why (thyroid and liver are fine). Has anyone else had high results for this?
Thanks

[Ayesha]

What is SHBG?

[Taz2]

Hi. Did you have a specific reason for having your SHBG tested? I've never had this offered so I'm just curious.

It seems that a high level is usual in women on HRT as oestrogen increases it but as yours was high before starting it then I guess you do have to find another reason.

Tazx

[floraljo]

It was just included in my medichecks package

[ccariad]

Hi SHBG - sex hormone binding globulin is increased with high intensity exercise, hyperthyroidism, type 1 diabetes and low body weight/bmi. It binds to circulating hormones so if its high you have less available oestrogen and testosterone at the cellular level - ie where we need it to do the job of reducing negative symptoms of low oestrogen/testosterone.

[Ayesha]

Hi SHBG - sex hormone binding globulin is increased with high intensity exercise, hyperthyroidism, type 1 diabetes and low body weight/bmi. It binds to circulating hormones so if its high you have less available oestrogen and testosterone at the cellular level - ie where we need it to do the job of reducing negative symptoms of low oestrogen/testosterone.

Many thanks for the very comprehensive explanation, I had never heard of this before.  The body such a complex machine!

[laszla]

Yes I have very high SHBG and it is the bane of my existence as I don't absorb oestrogen or testosterone and this might be the cause. I have low BMI which might account for it. Oral oestrogen is thought to increase it but not transdermal.

[floraljo]

My bmi is normal albeit at the very low end. I didn't realise it might affect absorption of hormones.

[Tracylou]

Yes, mine is very high. It was tested as part of my blood test to check my testosterone levels. I asked my gp why it was so high but she didn't know! It's come down very slightly since starting Tostran but still much higher than anyone else I've come across.

[floraljo]

Laszla - I'm in the same situation as you with high SHBG. May I ask how do you know if it is affecting your oestrogen absorption? Thanks