I was on Evorel (combined for a good year as was still having regular periods). I felt great on it but after a year started bleeding at odd times. Had a ultrasound and had thickened and cystic lining. I had to have a biopsy and hysterascopy and also had the Mirena fitted. All tests came back clear and now gone onto hrt patches evorel 50 only. Hoping I will feel as good on this as I did on the sequi. Would love to hear some success stories.