Hi, some of us change twice weekly patches every 3 days (rather than 3.5 or 4 days) to keep levels up & avoid resurgence of symptoms towards the end of a patch's life.
Studies have shown some variation over the life of each patch & some women are sensitive to this, so might be worth changing at 3 days if you've not tried this yet. Sorry, can't remember brands tested, but assume applies to some extent with all.
Wx