Hopeful - I am EXACTLY the same as you re increasing dose and causing bad symptoms. Have just posted about it. I feel for you I really do this is total rubbish isn't it xx I have copied and pasted my post here .....''Hi All, I have been struggling for ages to try and get my HRT levels to even out. I am post meno, surgical menopause many years ago and aged 70. Been on oestrogen only HRT since I was 42. Was absolutely fine HRT wise till last year when oestrogel became unavailable and then was put on Lenzetto and then two different patches which I never levelled out on. Started back on Oestrogel in July and just can't get level. Had loads of blood tests in Sept like thyroid etc all came back normal. My oestrogen blood level however was low in July at 69 and Meno consultant told me to work up to 3 pumps of Oestrogel (which I was originally on). Have been trying to work up over the months as have to take it slowly as am super sensitive to any level change but every time I went up (got up to 2 1/2) it made me feel dreadful to be honest its been horrendous with cracking headaches, dizziness, huge anxiety, feel wired and jittery all the time, insomnia and episodes of palpitations which are all supposed I thought to be signs of too little oestrogen but the higher up I went the worse I felt. Hence over the past 2 weeks I have come down on the dose and am now on 1 1/2 pumps. I notice the oestrogen in Oestrogel which used to be Estradiol 17b changed last year to Estradiol hemihydrate and I am wondering if it is maybe a bit stronger. I did write to the manufacturer but they told me nothing has changed which is odd as the main ingredient has for sure. I just wondered if anyone else suffered from too high a dose of their HRT and if so did they have similar symptoms. I had a spell of really bad muscle pain as well but that seems to have got better since I decreased the dose. My blood oestrogen levels were low in July but I felt a lot better then than I do now so maybe I should be going on symptoms and not blood levels which is what the Meno consultant seems to want me to do? I have a follow up telephone appt on 1st Dec but really am finding it hard to function at any level right now. I realise it will take time to level out on the lower dose too. Any input would be very much appreciated - thanks so much xxx''