Yes, absolutely. I'm 11 years post menopause and 2 years ago, started with hot flushes and really low mood. Never connected it to menopause. Thought i was well past that but i was seen by an endocrinologist who ran lots of tests, and I mean lots of tests!, and then confirmed that in her opinion the remaining circulating estrogen that we all have after menopause had taken a 'catastrophic drop' thus producing menopausal symptoms again. Apparently she assured me this does happen to some women. I sailed through my 'first' menopause with little more than a mood swing that id been happily taking a very small dose of antidepressant for 10 years for what they have classed 'menopausal mood' rather than depression, but this one has floored me. My GP told me she has found that if a patient had an easy menopause first time around then it can bite back again years later! No idea how true that is. Early morning anxiety, adrenaline rushes, palpitations, sleeplessness, cold chills when I stand up, a feeling that one of Harry Potter's Dementors has moved in to my head and is running the show!! My mood is so up and down and this from someone who has never suffered with depression or anxiety in my life. Don't feel like 'me' at all. No joy whatsoever. Started on HRT a year ago at the age of 62 but I was willing to try anything. So far HRT hasn't cracked the 'sweet spot' as my endocrinologist likes to call it and I remain 'flat' in mood. Anxiety comes and goes but is better. I see her again next week and have just this morning been for my estradiol bloods prior to my appointment with her so we shall see what she has up her sleeve next week. I think if we are going to continue with HRT, Im well overdue a 'tweek'. Testosterone has been mentioned too but only when she can see my estrogen is up to an acceptable level. It's a whole new world I had no idea existed!!