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[Tora]

Thanks Joaniepat, very handy knowing the licensing dose.

[Haydo]

Thanks Jenna and Marchlove - interesting links.

[joziel]

That link you posted Jenna, is incredibly interesting  Who'd have thought Vagifem can help with bone protection?? Marchlove thanks also for that one.

So it sounds like it does get absorbed systemically but not enough to take levels over menopausal range, so still considered safe and within what some women would have physiologically. (I'm not sure if that was taking it every day or if they were looking at taking it 2x weekly though, I need to read again.)

However, for me, trying to rule out estrogen as a cause of what I'm going through at the moment, maybe I need to be extra cautious especially about taking it every day. I'm going to try to go back to 2x weekly and see if my VA symptoms will stay away now. I mean, if my own ovaries have fired up again I should have my own systemic estrogen again. I don't have any of my other low estrogen symptoms back yet, no night sweats or joint pain etc.

I don't know what I'm going to do if I'm this sensitive to estrogen, when I do need it and become menopausal. I'm very worried. My working theory at the moment, is that it causes me to have high blood pressure (via some mechanism I don't understand) and it's the high blood pressure for 5 months which has caused my heart to get into these constant ectopics. Which it's having a hard time getting out of now, even though my blood pressure is now normal again. This is just my best guess whilst I wait to see the cardiology nurse specialist I've been referred to.

[Jenna]

I’m glad you found it interesting   

Maybe use a vaginal moisturiser on the days you don't use Vagifem - just to see how you get on for now.

[joziel]

Yes, I already use lots of other non-hormonal moisturisers. But when I get a VA flare, there's nothing quite like estrogen 

Talking of which, how does DHEA or Intrarosa fit into all this? Is that considered estrogen?? I think our bodies convert it into estrogen? But it might not be the same as actually taking external estrogen so I wonder if I'd be able to tolerate that if I can't have local estrogen.

[Jenna]

I think Marchlove knows about DHEA - she posted this link before:

https://www.agelessforever.net/bioidentical-estrogen-progesterone-hrt/dhea-why-it-is-especially-important-for-menopausal-women

[Ayesha]

What an interesting thread! I have been taking Vagifem pessary daily for nearly a year now with Ovestin locally. Just lately I have noticed slight hot flushes returning, and those palps I have read so much about on here too also mild anxiety like I used to get years ago.

I suffered very badly with night sweats and palpatations after a dose of covid at Christmas. Had ecg and was ok after a few weeks but this is common after covid and also the vaccination . Makes you think your HRT is not working.

Yes, I've been blaming it on the heatwave but am keeping an eye on how I feel each day going forwards.
Links posted on this thread make fascinating reading and very encouraging, thanks ladies for posting!

[joziel]

Thanks Jenna, will check that out.

Ayesha I don't think I get what you mean there. Are you saying that you are taking Vagifem and have noticed a return in your hot flushes and palps and you are thinking this is caused by the Vagifem? If so, I really wouldn't draw that conclusion.

I'm a very 'weird' case in that I am incredibly sensitive to estrogen and I'm just trying to recover from taking systemic estrogen for 5 months at the moment and wondering if, for me in my hyper-sensitised state at the moment, the daily Vagifem + Ovestin (which I've been liberally applying externally 2x daily!) is keeping the palps going.

I very much doubt if Vagifem is enough estrogen to cause this in 99% of other women (especially seeing it's not going to make much difference if you are already on systemic HRT as it's just a drop more). So I really wouldn't be thinking about Vagifem in your situation, I'd be thinking that you probably need more estrogen if you were fine for a while and then appeared to get some symptoms back.

[Ayesha]

Thanks, Joziel, your comments are encouraging.

Last week I was getting symptoms that I used to get 20 years ago during the menopause. High anxiety feelings and mild hot flushes. Anxiety feelings subsiding by the afternoon and all was calm again.
I am good at overthinking things and I thought perhaps the Vagifem and the Ovestin, which I use a tiny amount of locally, but might increase it a bit more if I feel I need to to keep my VA under control!
It could have been anything causing these issues and the last few days I have been fine. This is me trying to understand my aging body and its changes 

[joziel]

Hot flushes are a sign of low estrogen, so it might be that you need a little dose adjustment. Just do the smallest adjustment possible is my advice 

[joziel]

Well I think I’ve disproven my own theory as tonight is my second night not on Vagifem or Ovestin and I’m still palping away. I’ve been so fine all day I really hoped tonight was the night it would all stop but no luck….

[Jenna]

I think you need to give it more time for your theory to work before despairing, joziel.   

[joziel]

I can’t really do that or my VA will come back.

[Jenna]

That does make it very difficult then - I can only think of trying to manage with moisturisers in the short term just to test your theory out and see if there was an improvement.

[joziel]

Yes, I'm using moisturisers but I tend to find they are not enough usually.

I do think that 48hrs off all estrogen should really be enough to notice a difference with the palps. Hopefully Vagifem 2x weekly is okay for the VA again...

Meanwhile I'm actually going to get a call from cardiology dept tomorrow about my symptoms so they can decide whether to try to bring my appointment forwards (currently 15th Sept).