Other than the soy, yam ingredient there's really not much difference, other than the size of the patch, estradot are very small and stick extremely well, they also have a softer surface which doesn't go hard and stiff after bathing where has I found with everol they do go hard and almost crinkled after bathing/showering, everol patches are huge in comparison, and don't stick aswell in my experience, I've been on both and dispite the size I preferred everol, estradot unfortunately gave me too many side effects that I couldn't tolerate, it's different for everyone, try the everol and see how you go, you can always request estradot if you don't like /get on with them.