:'(please help I am 63 had hystorectomy 20 years ago for fybroids and later prolapse repair.i have used vagifem for passed 12 yrs on and off . But over last 2 years I have had to use 3 and 4 for a week as estrogen drops I get bladder cramps.i worried if they cause cancer .or fybroids or any other cancer.i am a super anxious person ..Dr says its fine to use vagifem all the time up to 5 week as low absorption. But dose anyone else get low bladder cramps backache...I have had poo samples done ct scan ultrasound scan internal and external over passed 2 years. No one seems to have these problems. There is no one who seems to understand iv been told its ibs .even told speak to GUM services or menopause help line .iv been on Louise Newsham on utube she is great but a one off sadly.moan over sorry to go on