I posted a while back about waking up many times a night. Usually between 4 and 7 times. I haven't slept through the night in probably 4 years, but it was getting worse. I work a full time job and felt like a walking zombie. In addition to the frequent waking, I was starting to have trouble falling asleep as well.
Previously I had been on Trisequens for a few years for mood swings and hot flashes and it worked well for those things. After experiencing symptoms of VA and irritable bladder, I finally got in to see a specialist that found a polyp in my uterus and removed it.
She prescribed Estrogen gel and Prometrium (200mg Progesterone) tablets at night. I started three nights ago and for the first time in forever I'm sleeping through or waking just once for a couple of minutes before falling back to sleep.
Early days, but it now seems that my disturbed sleep was related to low progesterone. Posting in case this information is useful for someone else. YMMV.