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[BohoChick]

I am a new user of estrogen patches - I started a once-weekly patch three weeks ago.

I have a theory about these patches from a pharmacologic standpoint. 

I don't think these patches (at least the once-weekly ones) do what they say with regards to maintaining a steady dosage.  Like - at all.  I know that in any medication regimen, it's going to be difficult to establish a truly levelized therapy - but I do think that these estrogen patches may be fudging some of the number more than other types of transdermal medications.

For the first ~24hrs after I apply a new patch, I have a varying number of symptoms, but I am noticing a pattern after my third patch.  I apply my new patches on a Friday evening, and I spend the entirety of Friday night and Saturday with VERY sore, stiff legs.  I hobble around the house like an old lady.  I also notice throughout the course of Saturday and Sunday, my vaginal dryness/VA and mood also show very marked improvement.  On Friday nights after applying the new patch, I actually almost feel a bit high.

I acknowledge that HRT seems to be complicated by the fact that the placebo-effect is quite high with it as well, but I am definitely NOT imagining the sore leg thing. 

I have also noticed that - throughout the week - it's almost like my body will "hit" a new reservoir of estrogen in the patch and I start feeling pretty good again. 

It's really weird but......personally, I don't see how these patches can maintain a steady dosage.  Especially the older generic types that don't have the funding behind them of the big drug companies to innovate new delivery systems. 

Thoughts?

[Perinowpost]

Have you thought about switching to one of the twice weekly patches such as evorel? I can vouch that they are extremely consistent x

[Nas]

What once weekly patch are you on?
I have only heard of the the twice weekly ones.

[Floradora]

Femseven is a once weekly one Nas. I tried it years ago but it made me itch and kept falling off! The Femsevensequi and Femsevenconti have the same progestogen in them as the Mirena coil -levonorgestrel.  It was the very first HRT I was on actually but I didn’t get on with the progesterone in it as well as the itching x

[Floradora]

Bohochick, I did see a study somewhere about the pharmacokinetics of transdermal patches and it did show that with the 7 day ones there was quite a boost in the first day, then fairly steady for about the next 4 or 5 days and then it dropped quite sharply at the end so that could well be what you are experiencing. I was put on a Femseven 7 day one by my gynecologist years ago and he told me to change it every 6th day due to levels tailing off quite a bit towards the end of the 7 days.

[Winterose]

I change my Evorel every 3 rd day and that helped a lot . I def know when I’m a day late .

I changed from Estradot to Evorel as felt better on Evorel but maybe Evorel has a better distribution rate ?

[Perinowpost]

I do the same Winterose x