My doctor has changed my betablocker from 1.25mg of bisoprolol a day to 45mg of propranolol a day. Bisoprolol was making no difference. I started the propranolol this morning (and duly waited for much anticipated awful side effects). However, I feel fine, although the palpitations, the reason why I am taking the pills, have been slightly worse today, along with my indigestion (for which I take lansoprazole daily). For anyone who has taken these tablets, does anyone know if they take a wee while to work? Also, has anyone taken a couple of glasses of wine with propranolol and lived to tell the tale? I know you are best not to drink at all with the tablets but I enjoy a couple of glasses with my evening meal. The wine and the bisoprolol were fine! Thanks ladies.