Hi MrsRoo, I too am really sorry to hear of your struggles with this, unfortunately I too am in the same situation, vagifem was a no go for me made things worse, ovestin no matter how much I use doesn't seem to make a difference, my gp said IC back in November gave me various treatments which helped but didn't take it away, at my hrt review in January my GP did say I could use ovestin as much as I like, I'm going to ask for the estring, as I think the fillers in both vagifem and ovestin irritate me, I don't understand why your GP, won't let you give another delivery method a go, mine is quite good at letting me choose, I would maybe push to try it, it may be the one thing that brings you relief, I really feel for you and hope you get some relief, I know how truly awful this feeling is, my worst symptom with this is the need to wee, I too don't have a solution but like flossieteacake said you definitely aren't alone.