I live in the United States. I have been on the Estradiol patch 0.025 for 11 months & Micronized Progesterone USP capsule vaginally inserted at bedtime 11 months. Around month 6 I started having calf pain & cramps. Fast forward to month 11 & both legs are in constant pain with severe cramps, spasms, heaviness, tingling, sharp pains, joint pains & weakness. My menopause specialist says it's not the HRT but that's the only thing different. She had me go to ER to rule out deep vein thrombosis & pulmonary embolism. My d-dimer blood test was normal but ER refused to perform a doppler ultrasound. I was told it could be vascular issues such as PAD, PVD, fibromyalgia, neurological or coming from my lower back. I'll be seeing my doctor a week from today to investigate further. I was reading some patients develop back & leg pain with HRT regardless if it's oral or transdermal. I will stop HRT for now until we figure out what's wrong. I can't even exercise, it hurts to walk, hurts constantly even at night. Please, rule out an vascular disease & possible blood clot issues.