Hello Hurdity, my gp decided to measure oestrogen levels as I was starting to get hot flushes and joint aches and pains. She wondered if the Estradot patches were not working effectively. The levels she felt were low considering I was using the patches so she wondered if a different means of administration of oestrogen ie. Oestrogel would be more effective. As I mentioned it was not and I have tried the gel for about 2 months with no effect on the symptoms, in fact they have become worse with added sleeplessness , anxiety and tearfulness. Today I had a phone call with the GP. She has re-prescribed Estradot 100mcg instead of 75mcg. I am hoping that this will settle things down again. TBH I wish I had not said anything in the first place as things may have settled on their own, just like happened for you. The GP may look at Testosterone too, she said “1 thing at a time, let’s settle the other symptoms first”