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[sprocket]

Hi there,
My level of oestradiol has gone up very high on 4 sprays of Lenzetto as has my TSH.

Does anyone have any knowledge of why this may be?
Although most of my symptoms have gone, I have recently begun having night sweats to the point where I am drenched.
So I am unsure about dropping the Lenzetto sprays down, but the 2390pmol level of oestradiol in the blood is worrying me.
I am almost 20 years post breast cancer.

Any advice?

[Nas]

Ooohh, a fellow BC survivor here too. I don’t think I’d be comfortable with that level of oestrogen in my blood either, to be honest.

Did you have the blood taken straight after your sprays, on that arm? That could account for your high reading ( which remember, can be reliably unreliable!)

If you have night sweats still, but no other symptoms, could your thyroid be over/under active?? 

Other than that, I don’t know 🤷‍♀️

[Amazing grace]

Night sweats and just feeling too hot and sweaty in the day can be a symptom of too much estrogen, most of the time ladies mention night sweats and the thought is always you need more but isn't always the case, in general the symptoms of too low/too high are very similar, I've had awful sweating on higher doses given your levels and being a bc survivor it would be best to consult with a medical professional to be safe.

[Nas]

Thinking about It, when I was on the gel, 4 pumps i think it was, my hands and forehead were always clammy.

I was told by my specialist, that women don’t usually need to be pumped full of hormones when post menopausal. Obviously if you are still symptomatic, then you need the extra.

[Wrensong]

I second Nas's question about having had blood taken from the arm where you applied the Lenzetto (I would retest, this time from unsprayed arm if so) & Amazing Grace's comment that high oestrogen could account for your night sweats.  As your body struggles to deal with a surfeit this could be part of the consequent stress response.

You say your TSH is very high too, I take it you mean above top of ref range?  Also can I ask did you test because you had a pre-existing thyroid condition?
 
Two thoughts on this . . .

1) if you are on thyroid replacement you probably need to increase your dose because oestrogen replacement increases Thyroid Binding Globulin, effectively making less of the active thyroid hormone available for use.  If you are hypothyroid you'll probably know that in theory this is only supposed to happen with oral oestrogen & not transdermal methods of delivery, but I'm long term hypothyroid, on transdermal oestrogen & have repeatedly had to tweak my thyroid replacement while trying to find my best HRT fit.  A few other hypothyroid members have reported the same response to transdermal oestrogen, though from memory they have been among the subset that like me, needs to take T3 as well as thyroxine, so we may be atypical in our response to HRT.  My very experienced Endocrinologist has also confirmed that exogenous oestrogen will affect TBG levels regardless of method of delivery.
 
2) if you are hypothyroid with a high TSH, indicating you need to increase your thyroid meds, your metabolism will be running slow, potentially hindering efficient clearance of oestrogen from your system, so your oestradiol level could be higher than it would be if your thyroid levels were optimal.

As an aside, night sweats have been my most resistant symptom & I suspect this may be because being hypothyroid predisposes us to thermoregulation problems even before menopause comes blundering in & hammers our thermostat.

The rock & hard place of needing HRT after breast cancer is an uncomfortable one & I really feel for you on that score.
Wx

P.S. for some reason I remembered you as postmenopause, but if not, any significant amounts of oestrogen you're still producing yourself will of course be adding to your high level.  Sorry if I've misunderstood.

[Floo36]

Are you peri menopause?. If so it’s most likely a fluctuation and not what your levels are all of the time. My Estrogen blood tests have never been helpful because of the extreme fluctuations, symptoms are your best way of knowing if it’s working.  Bloods can be useful once the fluctuations have stopped post menopause.  It can be very frustrating. 

[Postmeno3]

Hi,
I'm very new to Lenzetto, the specialist having deemed me a "poor absorber" from  bloods on other delivery methods. I should say I'm VERY postmeno! However, I've been considering a theory that, as it dries almost instantaneously, is it absorbed as quickly and, if so, how long is it effective for? I'm not going to spray on the morning of my next bloods. I do wonder, though, if spikes occur from extremely fast drying and subsequent absorption. Hmmmmm......🤔

[Sooty]

Hi,
I'm very new to Lenzetto, the specialist having deemed me a "poor absorber" from  bloods on other delivery methods. I should say I'm VERY postmeno! However, I've been considering a theory that, as it dries almost instantaneously, is it absorbed as quickly and, if so, how long is it effective for? I'm not going to spray on the morning of my next bloods. I do wonder, though, if spikes occur from extremely fast drying and subsequent absorption. Hmmmmm......🤔

Can I ask what hrt you were on previously? Ive used patches and gel and my levels are low on both. Wondering if its worth asking for the spray with it being another transdermal method

[Postmeno3]

Hi Sooty.
I was on both Evorel and Estradot patches at the lowest dose and then Oestrogel, again at minimum dosage. I'm not convinced it's an absorption issue, possibly more an insufficient dose to absorb? I have been a VERY long time without replacement therapy, oestrogen only. Hope that helps.