Hi Pippa, I stopped a trial of Lenzetto to go back to Estradot patches due to what felt like poor absorption from the spray. I also didn't get on well with Estrogel. Have used both Evorel & Estradot patches & bloods show I get approx 4x as much oestradiol from Estradot as I did from Evorel Conti. On EC I was getting less than half the expected absorption from a 50mcg patch & this was described as "disappointing" by the Meno clinic. I was advised to steer clear of all Evorel products in case the same poor absorption recurred with their oestrogen only patches, but many women do get on very well with them, so it's a very individual matter.
What suits me may not suit you, but if you want to get your levels up gradually it is possible to cut matrix patches & gradually increase later, should a particular dose feel too much. A good thing about Estradot is that they come in an intermediate 37.5mcg dose, instead of jumping from 25 to 50mcg. I also find they stick very well. To give you an idea of the kind of absorption I get from Estradot - on 25mcg: 180 pmol/L & on 37.5: 250-270. These are only snapshots of course.