Hi Flan, yeah I found that using the gel at night (I'm on three pumps), even with the Utrogestan, made me really wired and increased my pulse rate, and affected my sleep (what sleep I was getting that is). Switched to gel in the a.m. and that sorted it. As you are on six pumps (wow, can't they find you another way of getting the oestrogen you need?) you'll be pushed to find enough places all at once to put it on, maybe try splitting it during the morning? Maybe try out not using at night and see what happens, then take it from there? Best of luck xxx