Coincidence? I've used it for 5+ years at night, but it hasn't affected my moods etc..
It's so localised. 'vagifem' and 'ovestin' shouldn't have any effect on other replacement therapies. If the symptoms remain continue inserting every night for another 2 weeks. Vagisil ......... I put 'ovestin' on the inner and outer vaginal area so that I know what is working.