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[Polpringle]

I know this is talked about a lot here and everyone has there own opinion but does anyone take Utrogestan 100mg alternate days successfully?
I have moved onto a conti regime and felt so much better on the whole but some days feel tired/lethargic and I think it’s a build up from the progesterone. I did start alternate days at the beginning but had breakthrough spotting I’m wondering if now I’ve been taking a sufficient amount my lining will be thin enough to be able to start alternate days.
I’m 49 late Peri and have an appointment with my specialist at the end of the month

[Hurdity]

Hi Polpringle

With HRT and dosing it's less a question of opinion but more that of evidence and then has to be balanced against the effect of the recommended doses on the individual woman.

The alternate day Utrogestan regime is cautiously recommended off licence by some menopause specialists as a result of studies or maybe one small study showing that used vaginally (not orally) I think on alternate days, maybe one study 3 x per week (?),the endometrium is protected. As far as I recall this was for low and medium doses of oestrogen. I woud have to dig out the studies. There is a whole thread somewhere where I posted all the papers and summaries of their findings.

If you are still peri-menopausal then your own cycle could result in spotting or bleeding anyway. The thing is it is ongoing - so when you say you wonder if now you've been taking a sufficient amount, if your lining will be thin enough - well it may well be, now that you have taken the higher dose but the biological effects are dynamic. If the progesterone dose is not high enough (for you/your oestrogen dose) then the lining may gradually build up again and you will continue to get spotting.

The alternate day regime was not trialled with oral dosage (as far as I remember).

If your oestrogen dose is quite low then alt day vaginal dosing may well be sufficient as you become menopausal. Good that you are seeing a specialist and can discuss these issues.

I do sympathse re the progesterone overdosing and fatigue etc. There is no way I woud want to take it all the time hence remaining with a cycle even into my late 60's (!).

Hope this helps

Hurdity x

[Polpringle]

Thank you Hurdity you always show such knowledge!
I’m on 3 pumps of Estrogel which works right now for me, I wish I could stay on a cyclical regime but the ups and downs of the change in hormones lured made me feel suicidal at times.