I wonder if anyone can help me. I currently take 2mg of Sandrena Gel daily and ustrogen vaginally for 15 days of my cycle. I am still experiencing very low mood around the week before my period is due , I'm snappy and sensitive just like pmt really . Would an increase of Sandrena Gel around this time when I feel that I'm particularly struggling help ease those symptoms or am I already on the maximum dose. I'm 49 and peri.