I feel relieved that others feel the same. Yesterday I cut a quarter off the 75 Estradot and went to Morrison’s - I felt terrible, like something was missing and started to have panicky feelings. I got home, picked my son up from work still feeling panicky and when I got home I decided to change the patch to estraderm thinking that Estradot didn’t suit me after 1.5 years of suffering, I was grabbing at straws. I went to bed early and couldn’t sleep, I lay there and felt sick to my stomach. This morning I put an Estradot 75 patch back on in desperation. I have to face the fact that this is as good as it gets. The anxiety is Terrible this morning but I’m trying to talk myself down. My son was stressing last night about all the work he has to do for his apprenticeship and started crying and I started to crumble inside. This was preying on my mind also, my husband said that if he can’t keep up its time to look for something else, I felt broken. An over reaction, something I would normally handle but I don’t cope with stress anymore for some reason. Anyway, what I’m trying to say is that by messing about with the hrt, I am now worse off so I agree, it’s hard to imagine feeling worse, but today I do. I will have to leave the hormones alone as I have tried everything in an effort to escape the anxiety but am by far worse off today, I am so sensitive to hormone change, it’s unreal. I appreciate you taking the time to read this. Ridiculously my husband and son slept well last night whilst I slept restlessly again, they have no idea what I’m going through and my husband doesn’t understand. He has tried but his eyes keep glaze over as I try my best to explain. As you say blitzen5, it’s hard to strike a balance and I hope you get some answers from the meno clinic, please me know how you get on. I have tried increasing the patch, decreasing the patch, changing the patch, trying oestrogel, trying no patch, you name it, I have tried over the course of two years. I have also tried regarding progesterone - mirena coil, utrogestan and Provera plus combined evorel patches. Estradot 75?and Provera for 14 days plus a tiny pea sized amount of tostran gel is the best I can hope for. This gives me horrendous morning anxiety, a feeling that I can’t cope which is maybe adrenal fatigue and not good sleep. Thanks for sharing your stories.