Thanks for asking. This thread has taken on a great direction. I'm slightly more irritated again so I'm thinking I should stop all these potions as my examination appointment came through today for a couple of weeks and we'll maybe both have a clearer idea of what we're dealing with. A face-to-face will be more useful, too, I think, as the phone felt rushed and anxiety-provoking. With the M.E., I don't process information fast enough or accurately enough over the phone. The thing is, I'm not (or wasn't!) sore at all externally, but I guess the thinking is the atrophy is wider spread than I realise. I'm only sore internally with soapy things, Epsom Salts and new relationship "fumblings" (sorry, tmi!). I'll stick with the Vagifem to boost the Estring and leave all the gunky stuff aside meantime. I've loads more other symptoms that really need systemic hrt. I tick, consistently, at least 25 of the 35 symptoms listed on the thread titled "Tired" with a few more intermittently. Then, the issue of what's causing what with the M.E. in the mix. I guess it's a bit complicated!