I had breast disease in the 1990s and my oncologist's parting words were "No HRT for you young lady". Well had I suffered half as much as some do I would have beaten on the door! As it was my GP recognised my VA and prescribed without hesitation. It is after all a very small amount of active ingredient.
Turning it on it's head: a bus might get you B4 the 'vagifem' causes cancer ;-).